These two peptides are cousins separated by one deliberate edit.
That tiny structural difference is why buyers often confuse AOD-9604 vs HGH Fragment 176-191—and why a laboratory should never treat the names as interchangeable.
AOD-9604 is the modified version; HGH Fragment 176-191 is the direct C-terminal growth-hormone fragment.
Both come from the tail end of human growth hormone. AOD-9604 was deliberately changed to create a distinct research analog.
AOD-9604 vs HGH Fragment 176-191 at a glance
| Question | AOD-9604 | HGH Fragment 176-191 |
|---|---|---|
| Basic identity | Modified C-terminal HGH fragment analog | Direct C-terminal HGH fragment |
| Common sequence description | Tyr-hGH177-191 | HGH residues 176-191 |
| Main research angle | Drug-development analog and lipid-metabolism models | Fragment biology and sequence comparisons |
| Full-length HGH? | No | No |
| Certiva vial sizes | 5 and 10 mg | 1, 2, 5, 10, 12, and 15 mg |
The simplest picture is a copied sentence with one purposeful edit. Most of the letters are related. The edit creates a different reference material.
What is HGH Fragment 176-191?
Human growth hormone is a 191-amino-acid protein. HGH Fragment 176-191 is a short sequence taken from its C-terminal, or tail-end, region.
Researchers became interested in that region because early animal work connected it with lipid metabolism.
A rat study of the synthetic C-terminal sequence reported antilipogenic activity. Antilipogenic means reducing the creation or storage of new fat. The same study did not find a significant lipolytic effect under its test conditions.
Read the original HGH C-terminal fragment paper on PubMed.
The useful buying point is straightforward: HGH Fragment 176-191 is selected when the fragment itself is the reference the laboratory wants to study.
What is AOD-9604?
AOD-9604 is a modified analog derived from the same C-terminal region. Scientific papers commonly describe it as Tyr-hGH177-191.
The “Tyr” matters. It refers to an extra tyrosine added at the front of the 177-191 sequence. This creates a 16-amino-acid analog instead of simply copying the unmodified tail sequence.
That modified peptide became a drug-development research candidate centered on lipid metabolism and energy balance.
In obese-mouse research, chronic AOD-9604 treatment was associated with increased lipolytic sensitivity and changes in body weight. The study also examined the beta-3 adrenergic receptor pathway. See the AOD-9604 mouse study on PubMed.
The important commercial distinction is not “better fat burning.” It is modified analog versus direct fragment reference.
Are AOD-9604 and HGH Fragment 176-191 the same?
No. They share the same scientific family, but the exact sequence and name matter.
You may see loose marketing use “AOD-9604,” “HGH frag,” and “176-191” as if all three labels mean the same vial. That shortcut is not good enough for a research order.
A buyer should ask:
- Is the material the modified Tyr-hGH177-191 analog?
- Is it the direct HGH Fragment 176-191 sequence?
- Does the identity test match that exact sequence?
If the supplier cannot answer those questions, the product name is not specific enough.
Which is better: AOD-9604 or HGH Fragment?
Choose based on the experimental target:
- Choose AOD-9604 when the study needs the modified drug-development analog or wants to reproduce AOD-specific preclinical work.
- Choose HGH Fragment 176-191 when the study needs the direct C-terminal fragment or a wider set of vial-size options.
- Choose separate vials of both when the project compares the structural modification with the direct fragment.
Neither product is full-length HGH. For a laboratory comparison, that is not a weakness—it is the entire point of studying a smaller, more focused sequence.
What vial sizes are available?
Certiva supplies:
- AOD-9604: 5 mg and 10 mg per vial;
- HGH Fragment 176-191: 1 mg, 2 mg, 5 mg, 10 mg, 12 mg, and 15 mg per vial; and
- standard packaging: 10 vials per box.
Bulk quantities and custom requests are available by inquiry.
What should the COA show?
Purity is only half the question. Closely related peptides make identity especially important.
Check:
- the exact product and sequence name;
- the vial amount;
- the matching batch number;
- the HPLC purity profile;
- mass-spectrometry identity information; and
- storage and shipping conditions.
Our guide to HPLC vs mass spectrometry explains why one test supports purity while the other helps confirm identity.
Which material fits the research question?
AOD-9604 is the purpose-built modified analog. HGH Fragment 176-191 is the direct fragment reference.
The names are related, but they should not be swapped on an inquiry, invoice, vial, or COA.
Certiva supplies both materials strictly for laboratory research use only, not for human consumption.
Compare the current batches
Tell us which peptide, vial size, box quantity, destination, and documents your project requires. We will reply with availability, applicable batch information, lead time, and a quote.
Compare AOD-9604 and HGH Fragment COAs →
Sources and further reading
- PubMed: C-terminal hGH fragment and lipid-metabolism research
- PubMed: AOD-9604 lipid-metabolism research in obese mice
Frequently asked questions
What is the main difference between AOD-9604 and HGH Fragment 176-191?
AOD-9604 is the modified version; HGH Fragment 176-191 is the direct C-terminal growth-hormone fragment.
Is AOD-9604 the same as HGH Fragment 176-191?
They are closely related but not identical. AOD-9604 is commonly described as Tyr-hGH177-191, a modified analog with an added N-terminal tyrosine, while HGH Fragment 176-191 is supplied as the direct C-terminal fragment reference.
Which is better, AOD-9604 or HGH Fragment 176-191?
AOD-9604 is the clearer choice for studies of the deliberately modified drug-development analog. HGH Fragment 176-191 is the clearer choice for direct C-terminal fragment and sequence-comparison research.
Are AOD-9604 and HGH Fragment full-length growth hormone?
No. Both are short peptides connected to the C-terminal region of the 191-amino-acid human growth-hormone sequence. Neither is full-length HGH.
What vial sizes does Certiva supply?
Certiva supplies AOD-9604 in 5 and 10 mg vials and HGH Fragment 176-191 in 1, 2, 5, 10, 12, and 15 mg vials, with 10 vials per standard box.
For research use only. Not for human consumption. This article is educational and makes no medical, therapeutic, or dosing claims.
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